Acids and Bases :
Cox, Brian G.
Acids and Bases : Solvent Effects on Acid-base Strength / Brian G. Cox, AstraZeneca Macclesfield, UK. - First edition. - UK, Oxford University Press ; c2013. - xii, 143 pages : illustrations ; 25 cm.
Includes bibliographical references and index.
1. Introduction -- 2. Acid-base equilibria: quantitative treatment -- 3. Solvation and acid-base strength -- 4. Determination of dissociation constants -- 5. Protic solvents -- 6. High-basicity polar aprotic solvents -- 7. low-basicity and low-polarity aprotic solvents -- 8. Acid-base equilibria and salt formation -- 9. Appendices: dissociation constants in methanol and aprotic solvents.
Acids and bases are ubiquitous in chemistry. Our understanding of them, however, is dominated by their behaviour in water. Transfer to non-aqueous solvents leads to profound changes in acid-base strengths and to the rates and equilibria of many processes: for example, synthetic reactions involving acids, bases and nucleophiles; isolation of pharmaceutical actives through salt formation; formation of zwitter-ions in amino acids; and chromatographic separation of substrates. This book seeks to enhance our understanding of acids and bases by reviewing and analysing their behaviour in non-aqueous solvents. The behaviour is related where possible to that in water, but correlations and contrasts between solvents are also presented. Fundamental background material is provided in the initial chapters: quantitative aspects of acid-base equilibria, including definitions and relationships between solution pH and species distribution; the influence of molecular structure on acid strengths; and acidity in aqueous solution.--
9780199670512 (hbk) 019967051X (hbk) 9780199670529 (pbk.) 0199670528 (pbk.)
2012554149
016171898 Uk
Solvents.
Acids.
Bases (Chemistry)
Acids.
Bases (Chemistry)
Solvents.
QD477 / .C69 2013
546.24
Acids and Bases : Solvent Effects on Acid-base Strength / Brian G. Cox, AstraZeneca Macclesfield, UK. - First edition. - UK, Oxford University Press ; c2013. - xii, 143 pages : illustrations ; 25 cm.
Includes bibliographical references and index.
1. Introduction -- 2. Acid-base equilibria: quantitative treatment -- 3. Solvation and acid-base strength -- 4. Determination of dissociation constants -- 5. Protic solvents -- 6. High-basicity polar aprotic solvents -- 7. low-basicity and low-polarity aprotic solvents -- 8. Acid-base equilibria and salt formation -- 9. Appendices: dissociation constants in methanol and aprotic solvents.
Acids and bases are ubiquitous in chemistry. Our understanding of them, however, is dominated by their behaviour in water. Transfer to non-aqueous solvents leads to profound changes in acid-base strengths and to the rates and equilibria of many processes: for example, synthetic reactions involving acids, bases and nucleophiles; isolation of pharmaceutical actives through salt formation; formation of zwitter-ions in amino acids; and chromatographic separation of substrates. This book seeks to enhance our understanding of acids and bases by reviewing and analysing their behaviour in non-aqueous solvents. The behaviour is related where possible to that in water, but correlations and contrasts between solvents are also presented. Fundamental background material is provided in the initial chapters: quantitative aspects of acid-base equilibria, including definitions and relationships between solution pH and species distribution; the influence of molecular structure on acid strengths; and acidity in aqueous solution.--
9780199670512 (hbk) 019967051X (hbk) 9780199670529 (pbk.) 0199670528 (pbk.)
2012554149
016171898 Uk
Solvents.
Acids.
Bases (Chemistry)
Acids.
Bases (Chemistry)
Solvents.
QD477 / .C69 2013
546.24