Characterization of impurities and degradants using mass spectrometry
Characterization of impurities and degradants using mass spectrometry [electronic resource] /
edited by Birendra N. Pramanik, Mike S. Lee, Guodong Chen.
- Hoboken, N.J. : John Wiley, c2011.
- 1 online resource (1 online resource (xxii, 462 p.)) : ill.
- Wiley series on pharmaceutical science and biotechnology. .
- Wiley series on pharmaceutical science and biotechnology. .
Includes bibliographical references and index.
Frontmatter -- Methodology. Introduction to Mass Spectrometry / Scott A Smith, Ruth Waddell Smith, Yu Xia, Zheng Ouyang -- LC Method Development and Strategies / Gang Xue, Yining Zhao -- Rapid Analysis of Drug-Related Substances Using Desorption Electrospray Ionization and Direct Analysis in Real Time Ionization Mass Spectrometry / Hao Chen, Jiwen Li -- Orbitrap High-Resolution Applications / Robert J Strife -- Structural Characterization of Impurities and Degradation Products in Pharmaceuticals Using High-Resolution LC-MS and Online Hydrogen/Deuterium Exchange Mass Spectrometry / Guodong Chen, Birendra N Pramanik -- Isotope Patten Recognition on Molecular Formula Determination for Structural Identification of Impurities / Ming Gu -- Application. Practical Application of Very High-Pressure Liquid Chromatography across the Pharmaceutical Developmentb6sManufacturing Continuum / Brent Kleintop, Qinggang Wang -- Impurity Identification for Drug Substances / David W Berberich, Tao Jiang, Joseph McClurg, Frank Moser, R Randy Wilhelm -- Impurity Identification in Process Chemistry by Mass Spectrometry / David Q Liu, Mingjiang Sun, Lianming Wu -- Structure Elucidation of Pharmaceutical Impurities and Degradants in Drug Formulation Development / Changkang Pan, Frances Liu, Michael Motto -- Investigation of Degradation Products and Extractables in Developing Topical OTC (Over the Counter) and NCE (New Chemical Entity) Consumer Healthcare Medication Products / Fa Zhang -- Characterization of Impurities and Degradants in Protein Therapeutics by Mass Spectrometry / Li Tao, Michael Ackerman, Wei Wu, Peiran Liu, Reb Russell -- Identification and Quantification of Degradants and Impurities in Antibodies / David M Hambly, Himanshu S Gadgil -- Index.
Online version restricted to NUS staff and students only through NUSNET.
System requirements: Internet connectivity; World Wide Web browser.
Mode of access: World Wide Web.
9780470921371 (electronic bk.) 0470921374 (electronic bk.) 9780470921364 (electronic bk.) 0470921366 (electronic bk.)
10.1002/9780470921371 Wiley InterScience
Drugs--Analysis.
Drugs--Spectra.
Mass spectrometry.
Contamination (Technology)
Mass Spectrometry--methods.
Pharmaceutical Preparations--analysis.
Drug Contamination.
RS189.5.S65 / C53 2011
615.1
Includes bibliographical references and index.
Frontmatter -- Methodology. Introduction to Mass Spectrometry / Scott A Smith, Ruth Waddell Smith, Yu Xia, Zheng Ouyang -- LC Method Development and Strategies / Gang Xue, Yining Zhao -- Rapid Analysis of Drug-Related Substances Using Desorption Electrospray Ionization and Direct Analysis in Real Time Ionization Mass Spectrometry / Hao Chen, Jiwen Li -- Orbitrap High-Resolution Applications / Robert J Strife -- Structural Characterization of Impurities and Degradation Products in Pharmaceuticals Using High-Resolution LC-MS and Online Hydrogen/Deuterium Exchange Mass Spectrometry / Guodong Chen, Birendra N Pramanik -- Isotope Patten Recognition on Molecular Formula Determination for Structural Identification of Impurities / Ming Gu -- Application. Practical Application of Very High-Pressure Liquid Chromatography across the Pharmaceutical Developmentb6sManufacturing Continuum / Brent Kleintop, Qinggang Wang -- Impurity Identification for Drug Substances / David W Berberich, Tao Jiang, Joseph McClurg, Frank Moser, R Randy Wilhelm -- Impurity Identification in Process Chemistry by Mass Spectrometry / David Q Liu, Mingjiang Sun, Lianming Wu -- Structure Elucidation of Pharmaceutical Impurities and Degradants in Drug Formulation Development / Changkang Pan, Frances Liu, Michael Motto -- Investigation of Degradation Products and Extractables in Developing Topical OTC (Over the Counter) and NCE (New Chemical Entity) Consumer Healthcare Medication Products / Fa Zhang -- Characterization of Impurities and Degradants in Protein Therapeutics by Mass Spectrometry / Li Tao, Michael Ackerman, Wei Wu, Peiran Liu, Reb Russell -- Identification and Quantification of Degradants and Impurities in Antibodies / David M Hambly, Himanshu S Gadgil -- Index.
Online version restricted to NUS staff and students only through NUSNET.
System requirements: Internet connectivity; World Wide Web browser.
Mode of access: World Wide Web.
9780470921371 (electronic bk.) 0470921374 (electronic bk.) 9780470921364 (electronic bk.) 0470921366 (electronic bk.)
10.1002/9780470921371 Wiley InterScience
Drugs--Analysis.
Drugs--Spectra.
Mass spectrometry.
Contamination (Technology)
Mass Spectrometry--methods.
Pharmaceutical Preparations--analysis.
Drug Contamination.
RS189.5.S65 / C53 2011
615.1