Approaches to the conformational analysis of biopharmaceuticals / Roger L. Lundblad.Material type: TextSeries: Protein science seriesPublication details: Boca Raton : CRC Press/Taylor & Francis, 2010.Description: 366 p. ; [ca. 23-29] cmISBN:
- 9781439807804 (hardcover : alk. paper)
- RS431.P75 L86 2010
|Item type||Current library||Call number||Copy number||Status||Date due||Barcode|
|General Books||CUTN Central Library Medicine, Technology & Management||615.7 (Browse shelf(Opens below))||1||Available||8824|
Includes bibliographical references and index.
Introduction to biopharmaceutical conformational analysis : issues and methods -- Comparability of biotechnological/biologic products and biological generics -- Application of native electrophoresis for the study of protein conformation -- Affinity chromatography including hydrophobic interaction chromatography in the study of biopolymer conformation -- Size-exclusion chromatography and bimolecular conformation -- The use of analytical ultracentrifugation to study biomolecular conformation -- Use of differential scanning calorimetry to measure conformational change in proteins and other biomacromolecules -- Light scattering and biomacromolecular conformation -- Use of luminescence to measure conformational change in biopharmaceuticals with emphasis on protein and protein drug products -- Near-infrared (NIR) spectroscopy and macromolecular conformation -- The use of mid-infrared and Fourier transform infrared (FTIR) spectroscopy to study biomacromolecule conformation -- The use of Raman spectroscopy to evaluate biopharmaceutical conformation -- The use of UV-VIS spectrophotometry for the characterization of biopharmaceutical products -- The use of optical rotatory dispersion and circular dichroism to study therapeutic biomacromolecule conformation -- The use of nuclear magnetic resonance for the characterization of biotherapeutic products -- Use of chemical probes for the study of protein conformation -- The use of hydrogen exchange in the study of biopharmaceutical conformation -- Use of chemical modification for the conformational analysis of biopharmaceuticals -- The use of immunology to characterize biopharmaceutical conformation -- The use of limited proteolysis to study the conformation of proteins of biotechnology interest -- Other technologies for the characterization of conformational change in biopharmaceuticals -- Development of an experimental approach for the study of the conformation of a biological therapeutic product.
Also available as an electronic resource.