TY  - BOOK
AU  - Cox,Brian G.
TI  - Acids and Bases: Solvent Effects on Acid-base Strength 
SN  - 9780199670512 (hbk)
AV  - QD477 .C69 2013
U1  - 546.24 23
PY  - 2013///
CY  - UK
PB  - Oxford University Press
KW  - Solvents
KW  - Acids
KW  - Bases (Chemistry)
KW  - fast
N1  - Includes bibliographical references and index; 1. Introduction -- 2. Acid-base equilibria: quantitative treatment -- 3. Solvation and acid-base strength -- 4. Determination of dissociation constants -- 5. Protic solvents -- 6. High-basicity polar aprotic solvents -- 7. low-basicity and low-polarity aprotic solvents -- 8. Acid-base equilibria and salt formation -- 9. Appendices: dissociation constants in methanol and aprotic solvents
N2  - Acids and bases are ubiquitous in chemistry. Our understanding of them, however, is dominated by their behaviour in water. Transfer to non-aqueous solvents leads to profound changes in acid-base strengths and to the rates and equilibria of many processes: for example, synthetic reactions involving acids, bases and nucleophiles; isolation of pharmaceutical actives through salt formation; formation of zwitter-ions in amino acids; and chromatographic separation of substrates. This book seeks to enhance our understanding of acids and bases by reviewing and analysing their behaviour in non-aqueous solvents. The behaviour is related where possible to that in water, but correlations and contrasts between solvents are also presented. Fundamental background material is provided in the initial chapters: quantitative aspects of acid-base equilibria, including definitions and relationships between solution pH and species distribution; the influence of molecular structure on acid strengths; and acidity in aqueous solution.--
ER  -