basic principles and applications in biomedical research Rudin, M. (Markus) 1953- creator text bibliography Electronic books. si Singapore World Scientific [2020] 2020 3rd ed. monographic eng 1 online resource (xxxi, 768 p.) "The area of molecular imaging has matured over the past decade and is still growing rapidly. Many concepts developed for molecular biology and cellular imaging have been successfully translated to in vivo imaging of intact organisms. Molecular imaging enables the study of processes at a molecular level in their full biological context. Due to the high specificity of the molecular readouts the approach bears a high potential for diagnostics. It is fair to say that molecular imaging has become an indispensable tool for biomedical research and drug discovery and development today. This volume familiarizes the reader with the concepts of imaging and molecular imaging in particular. Basic principles of imaging technologies, reporter moieties for the various imaging modalities, and the design of targeted probes are described in the first part. The second part illustrates how these tools can be used to visualize relevant molecular events in the living organism. Topics covered include the studies of the biodistribution of reporter probes and drugs, visualization of the expression of biomolecules such as receptors and enzymes, and how imaging can be used for analyzing consequences of the interaction of a ligand or a drug with its molecular target by visualizing signal transduction, or assessing the metabolic, physiological, or structural response of the organism studied. The third edition has been extended considerably. This holds for the chapter on imaging modalities, which now includes sections on intravital microscopy and mass spectrometric imaging. All chapters have been updated and a new chapter on the challenges of translating molecular imaging solutions for clinical use has been added"--Publisher's website. Foreword to the first edition -- Foreword of the second edition -- Foreword to the third edition -- About the author -- Acknowledgment -- Introduction -- Methodologies. Imaging techniques. Molecular reporter systems. Design of molecular imaging probes -- Applications. Drug imaging. Imaging gene expression. Imaging the function of gene products. Monitoring cell migration. Molecular imaging : translational aspects -- Appendices. Physical constants. Mathematical formulae. Natural amino acids. Nucleotides -- Index. by Markus Rudin. Mode of access: World Wide Web. System requirements: Adobe Acrobat Reader. Includes bibliographical references and index. Molecular probes Diagnostic imaging Imaging systems in medicine QP519.9.M64 R83 2020 616.07/54 9781786346858 1786346850 https://www.worldscientific.com/worldscibooks/10.1142/q0204#t=toc https://www.worldscientific.com/worldscibooks/10.1142/q0204#t=toc WSPC 200515 20260416153406.0 000q0204 eng