000			02806cam a22003977a 4500
001			19108
003			CUTN
005			20150619152921.0
008			111208s2012 enka b 001 0 eng
010			_a 2011293621
016	7		_a101572294 _2DNLM
020			_a9780123849991
020			_a0123849993
035			_a(OCoLC)ocn711573687
040			_aNLM _beng _cNLM _dSFB _dYDXCP _dWSU _dCDX _dFRH _dDLC
042			_anlmcopyc _alccopycat
050	0	0	_aRC270.8 _b.D53 2012
060	0	0	_a2011 K-597
060	1	0	_aQZ 267
082	0	0	_a616.99/4042 _223
245	0	0	_aDNA repair in cancer therapy : _bmolecular targets and clinical applications / _cedited by Mark R. Kelley.
250			_a1st ed.
260			_aLondon ; _aWaltham, MA : _bElsevier/Academic Press, _c2012.
300			_axiii, 316 p. : _bill. ; _c29 cm.
504			_aIncludes bibliographical references and index.
505	0		_aIntroduction and overview of current targets: bench to clinic / Mark R. Kelley -- 2. MGMT a critical DNA repair gene target for chemotherapy resistance / Stanton L. Gerson and Lili Liu -- 3. Blockade of base excision repair: inhibition of small lesions results in big consequences to cancer cells / Melissa Fishel and Carlo Vascotto -- 4. PARP inhibitors -- scientific rationale and clinical development for cancer / Ruth Plummer, Nicola J. Curtin and Yvette Drew -- 5. Chemotherapy intervention by inhibiting DNA polymerases for therapeutic intervention / Anthony J. Berdis -- 6. Targeting the nucleotide excision repair pathway for therapeutic applications / John Turchi and Stephan M. Patrick -- 7. Homologous recombination and ATM/ATR targets / Henning Willers, Lee Zou and Heike N. Pfaffle -- 8. DNA double strand break repair by nonhomologous end joining and its clinical relevance / Michael Weinfeld and Susan Lees-Miller -- 9. Defective MMR-c-Abl-p73-GADD45alpha expression in cancer chemoresistance / David Boothman and Long Shan Li -- 10. DNA repair signaling targets / Susan Ashwell -- 11. Redox regulation of DNA repair and therapeutic / Millie M. Georgiadis -- 12. Personalized cancer medicine: DNA repair alterations is a promising predictive marker in cancer / Srinivasan Madhusudan -- 13. The role of DNA damage and repair in neurotoxicity caused by cancer therapies / Michael R. Vasko -- 14. Future directions with DNA repair inhibitors / Mark R. Kelley.
650		0	_aCancer _xTreatment _xGenetic aspects.
650		0	_aDNA repair.
650	1	2	_aDNA Repair.
650	1	2	_aNeoplasms _xdrug therapy.
650	2	2	_aNeoplasms _xgenetics.
700	1		_aKelley, Mark Richard, _d1957-
906			_a7 _bcbc _ccopycat _d2 _encip _f20 _gy-gencatlg
942			_2ddc _cBOOKS
999			_c15245 _d15245