000			02928cam a2200433 i 4500
001			20625
003			CUTN
005			20160503123302.0
008			130430t20132013enka b 001 0 eng
010			_a 2012554149
016	7		_a016171898 _2Uk
020			_a9780199670512 (hbk)
020			_a019967051X (hbk)
020			_a9780199670529 (pbk.)
020			_a0199670528 (pbk.)
035			_a(OCoLC)ocn835079607
040			_aAU@ _beng _cAU@ _erda _dOCLCO _dCDX _dUOH _dBTCTA _dUKMGB _dYDXCP _dCUD _dBWX _dIUL _dOCLCF _dMUU _dOCLCQ _dDLC
042			_alccopycat
050	0	0	_aQD477 _b.C69 2013
082	0	4	_a546.24 _223
100	1		_aCox, Brian G.
245	1	0	_aAcids and Bases : _bSolvent Effects on Acid-base Strength / _cBrian G. Cox, AstraZeneca Macclesfield, UK.
250			_aFirst edition.
260			_aUK, _bOxford University Press ; _cc2013.
300			_axii, 143 pages : _billustrations ; _c25 cm.
504			_aIncludes bibliographical references and index.
505	0		_a1. Introduction -- 2. Acid-base equilibria: quantitative treatment -- 3. Solvation and acid-base strength -- 4. Determination of dissociation constants -- 5. Protic solvents -- 6. High-basicity polar aprotic solvents -- 7. low-basicity and low-polarity aprotic solvents -- 8. Acid-base equilibria and salt formation -- 9. Appendices: dissociation constants in methanol and aprotic solvents.
520			_aAcids and bases are ubiquitous in chemistry. Our understanding of them, however, is dominated by their behaviour in water. Transfer to non-aqueous solvents leads to profound changes in acid-base strengths and to the rates and equilibria of many processes: for example, synthetic reactions involving acids, bases and nucleophiles; isolation of pharmaceutical actives through salt formation; formation of zwitter-ions in amino acids; and chromatographic separation of substrates. This book seeks to enhance our understanding of acids and bases by reviewing and analysing their behaviour in non-aqueous solvents. The behaviour is related where possible to that in water, but correlations and contrasts between solvents are also presented. Fundamental background material is provided in the initial chapters: quantitative aspects of acid-base equilibria, including definitions and relationships between solution pH and species distribution; the influence of molecular structure on acid strengths; and acidity in aqueous solution.--
650		0	_aSolvents.
650		0	_aAcids.
650		0	_aBases (Chemistry)
650		7	_aAcids. _2fast
650		7	_aBases (Chemistry) _2fast
650		7	_aSolvents. _2fast
906			_a7 _bcbc _ccopycat _d2 _encip _f20 _gy-gencatlg
942			_2ddc _cBOOKS
999			_c16248 _d16248