000			02792cam a2200373 a 4500
003			CUTN
005			20171110154935.0
008			110715s2010 njuac b 000 0 eng c
020			_a9789814299169
020			_a9814299162
042			_apcc
060	0	0	_a2010 H-500
060	1	0	_aQU 141
070	0		_aQP606.D46 _bD58 2010
082			_a572.86 _bHUB
100			_aHubscher, Ulrich
245	0	0	_aDNA polymerases : _bdiscovery, characterization, and functions in cellular DNA transactions / _cUlrich Hübscher ... [et al.].
260			_aNew Jersey : _bWorld Scientific, _cc2010.
300			_axv, 321 p. : _bill. (chiefly col.), ports. _c26 cm.
500			_aMaintenance of the information embedded in the genomic DNA sequence is essential for life. DNA polymerases play pivotal roles in the complex processes that maintain genetic integrity. Besides their tasks in vivo, DNA polymerases are the workhorses in numerous biotechnology applications such as the polymerase chain reaction (PCR), cDNA cloning, genome sequencing, nucleic acids-based diagnostics and in techniques to analyze ancient and otherwise damaged DNA. Moreover, some diseases are related to DNA polymerase defects, and chemotherapy through inhibition of DNA polymerases is used to fight HIV, Herpes and Hepatitis B and C infections. We have recently witnessed the discovery of an abundance of novel DNA polymerases in viruses, bacteria, archaea and eukaryotes with specialized properties whose physiological functions are only beginning to be understood. This book summarizes the current knowledge of these fascinating enzymes. It is intended for a wide audience from basic scientists, to diagnostic laboratories and to clinicians who seek a better understanding of these fascinating enzymes.
505	0		_aHistory and discovery of DNA polymerases -- DNA polymerases in the three kingdoms of life: bacteria, archaea and eukaryotes -- Structural and functional aspects of the prokaryotic and archaea DNA polymerase families -- Structural and functional aspects of the eukaryotic DNA polymerase families -- Global functions of DNA polymerases -- Viral DNA polymerases -- Synthetic evolution of DNA polymerases with novel properties -- DNA polymerases and diseases -- DNA polymerases and chemotherapy.
650		0	_aDNA polymerases.
650	1	2	_aDNA-Directed DNA Polymerase.
650	1	2	_aArchaea DNA Polymerase
650	1	2	_aViral DNA Polymerases
650	1	2	_aChemotherapy
700	1		_aSpadari, Silvio
700	1		_aVillani, Giuseppe
700	1		_aMaga, Giovanni
942			_2ddc _cBOOKS
504			_aIncludes bibliographical references.
906			_a7 _bcbc _cpccadap _d2 _encip _f20 _gy-gencatlg
999			_c23841 _d23841