000			02981cam a22003378i 4500
001			21946955
003			CUTN
005			20230622115724.0
008			210317s2021 flu b 001 0 eng
010			_a 2021007837
020			_a9780367643836 _q(hardback)
020			_a9780815346036 _q(paperback)
020			_z9781003124269 _q(ebook)
040			_aDLC _beng _erda _cDLC
042			_apcc
050	0	0	_aQP517.C45 _bF47 2021
082	0	0	_a571.74 _223 _bFER
100	1		_aFerrell, James Ellsworth, _eauthor.
245	1	0	_aUnderstanding cell signaling : _bmotifs, recurring themes, and the theory of nonlinear dynamics / _cJames Ferrell.
260			_aFL : _bCRC Press, _cc2022.
263			_a2108
300			_apages cm
504			_aIncludes bibliographical references and index.
505			_aPreface. Acknowledgements. 1. Introduction. 2. Receptors I: Monomeric Receptors and Ligands. 3. Receptors II: Multimeric Receptors and Cooperativity. 4. Downstream Signaling I: Stoichiometric Regulation. 5. Downstream Signaling II: Covalent Modification. 6. Downstream Signaling III: Regulated Production or Destruction. 7. Cascades and Amplification. 8. Bistability I: Systems with One-Time Dependent Variable. 9. Bistability II: Systems with Two Time-Dependent Variables. 10. Transcritical Bifurcations in Phase Separation and Infectious Disease. 11. Negative Feedback I: Stability and Speed. 12. Negative Feedback II: Adaption. 13. Adaption II: Incoherent Feed-Forward Regulation and State-Dependent Activation. 14. Negative Feedback 3: Oscillations. 15. Relaxation Oscillators. 16. Excitability. 17. Wrap-Up. Glossary. Index.
520			_a"All living cells continually detect and respond to external signals. This is true of prokaryotes, whether they are living alone or in biofilms, and it is even more manifestly true in multicellular eukaryotes, where communication between cells and coordination of the cells' behavior enables the organism to function as a unified whole. In large multicellular organisms like us humans, cells receive signals from their immediate neighbors through short-range signals like neurotransmitters and cell-surface molecules. They receive signals from more distant neighbors via longer-range diffusible molecules like morphogens, and from still-more distant neighbors by means of hormones that flow through the circulatory system. And they receive signals from the outside world via sense organs. Cells also monitor their own internal status, and there is a great deal of overlap between the cellular components involved in cell-cell communication and internal monitoring"--
650		0	_aCellular signal transduction.
776	0	8	_iOnline version: _aFerrell, James, _tUnderstanding cell signaling _dBoca Raton : Taylor & Francis, 2021. _z9781003124269 _w(DLC) 2021007838
906			_a7 _bcbc _corignew _d1 _eecip _f20 _gy-gencatlg
942			_2ddc _cBOOKS
999			_c39062 _d39062