Peptide and protein engineering for biotechnological and therapeutic applications /
Peptide and protein engineering for biotechnological and therapeutic applications /
[edited by] Pierre Rousselot-Pailley, Olga Iranzo.
- Singapore : World Scientific, c2023.
- 1 online resource (x, 509 p.)
Includes bibliographical references and index.
Cis-amide stabilizing proline analogs: synthesis and applications -- Antimicrobial peptides and peptidomimetics as treatment option for Helicobacter pylori infection -- Antimicrobial ribosomally synthesized and post-translationally modified peptides as a source of alternatives to antibiotics: a focus on the Sactipeptides and Ranthipeptides subclasses -- Peptide nanotubes as dynamic materials -- Peptide- and protein-based nanomaterials for theranostics -- Engineering peptidyl and protein glutathione peroxidase mimics -- DNA recognition with artificial metallopeptides -- Recombinant production, isotopic labeling, purification and NMR characterization of cysteine-rich domains: the case of the death receptors involved in cancer treatment -- Substrate binding free energy profiles: probing enzyme-substrate interactions by molecular dynamics simulations -- Peptide-based artificial metalloenzymes by design -- Biohybrid catalysts harboring synthetic metal complexes within [beta]-Barrel proteins -- Chemistry for a better life: elaborating artificial metalloenzymes for eco-compatible chemical synthesis procedures and therapeutic applications.
"Peptides and proteins are crucial biomolecules in life. The manifold functions they carry out range from molecular recognition and signaling to catalysis and immune response. However, the native systems are limited to a reduced toolbox of chemical functionalities as well as tridimensional structures. Widening these toolboxes could pave the way to engineer peptides and proteins with enhanced properties compared to their native counterparts and/or with structures and functions unprecedented in Nature. Advances in the chemical and biological synthesis of peptides and proteins, in computational tools, in molecular biology and in high-throughput screening methods are making this realm possible. This book aims to give an overview of the last developments in the field of peptide and protein engineering. It comprises a collection of chapters that span from the production of simple non-proteinogenic building blocks and peptidic scaffolds of different sizes and structures to more complex systems including peptide-based nanomaterials, enzymes and artificial metalloenzymes. Different strategies are described where chemical and biological tools have been developed and combined to attain the desired properties and sought functionalities. The diverse systems described in this book highlight the progress in this important field and represent the starting points for the development of functional biomolecules, biomaterials and hybrid systems capable of addressing key societal challenges of our times in relevant areas such health, environment and energy"--
Mode of access: World Wide Web.
System requirements: Adobe Acrobat Reader.
9789811261664 9811261660
2022037229
Protein drugs.
Peptide drugs.
Electronic books.
RS431.P75
615.19
Includes bibliographical references and index.
Cis-amide stabilizing proline analogs: synthesis and applications -- Antimicrobial peptides and peptidomimetics as treatment option for Helicobacter pylori infection -- Antimicrobial ribosomally synthesized and post-translationally modified peptides as a source of alternatives to antibiotics: a focus on the Sactipeptides and Ranthipeptides subclasses -- Peptide nanotubes as dynamic materials -- Peptide- and protein-based nanomaterials for theranostics -- Engineering peptidyl and protein glutathione peroxidase mimics -- DNA recognition with artificial metallopeptides -- Recombinant production, isotopic labeling, purification and NMR characterization of cysteine-rich domains: the case of the death receptors involved in cancer treatment -- Substrate binding free energy profiles: probing enzyme-substrate interactions by molecular dynamics simulations -- Peptide-based artificial metalloenzymes by design -- Biohybrid catalysts harboring synthetic metal complexes within [beta]-Barrel proteins -- Chemistry for a better life: elaborating artificial metalloenzymes for eco-compatible chemical synthesis procedures and therapeutic applications.
"Peptides and proteins are crucial biomolecules in life. The manifold functions they carry out range from molecular recognition and signaling to catalysis and immune response. However, the native systems are limited to a reduced toolbox of chemical functionalities as well as tridimensional structures. Widening these toolboxes could pave the way to engineer peptides and proteins with enhanced properties compared to their native counterparts and/or with structures and functions unprecedented in Nature. Advances in the chemical and biological synthesis of peptides and proteins, in computational tools, in molecular biology and in high-throughput screening methods are making this realm possible. This book aims to give an overview of the last developments in the field of peptide and protein engineering. It comprises a collection of chapters that span from the production of simple non-proteinogenic building blocks and peptidic scaffolds of different sizes and structures to more complex systems including peptide-based nanomaterials, enzymes and artificial metalloenzymes. Different strategies are described where chemical and biological tools have been developed and combined to attain the desired properties and sought functionalities. The diverse systems described in this book highlight the progress in this important field and represent the starting points for the development of functional biomolecules, biomaterials and hybrid systems capable of addressing key societal challenges of our times in relevant areas such health, environment and energy"--
Mode of access: World Wide Web.
System requirements: Adobe Acrobat Reader.
9789811261664 9811261660
2022037229
Protein drugs.
Peptide drugs.
Electronic books.
RS431.P75
615.19