Molecular biology of diabetes / (Record no. 35746)

MARC details
000 -LEADER
fixed length control field 03557nam a22002297a 4500
003 - CONTROL NUMBER IDENTIFIER
control field CUTN
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20210809114749.0
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 210809b ||||| |||| 00| 0 eng d
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
International Standard Book Number 9781461266778
041 ## - LANGUAGE CODE
Language English
082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER
Edition number 23
Classification number 616.462
Item number DRA
100 ## - MAIN ENTRY--PERSONAL NAME
Personal name Draznin, Boris;
245 ## - TITLE STATEMENT
Title Molecular biology of diabetes /
Remainder of title Autoimmunity and genetics; insulin synthesis and secretion.
Statement of responsibility, etc Boris Draznin; Derek LeRoith
260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT)
Place of publication, distribution, etc Totowa, N.J. :
Name of publisher, distributor, etc Humana Press,
Date of publication, distribution, etc ©1994.
300 ## - PHYSICAL DESCRIPTION
Extent VI, 404 p. :
Other physical details illustrations ;
Dimensions 24 cm
505 ## - FORMATTED CONTENTS NOTE
Contents Preface
Title Section I: Molecular Mechanisms of Autoimmunity and Genetics of Diabetes. Molecular Targets of the Autoimmunity of Type I Diabetes. Murine Transgenic Models of IDDM. Pancreatic Islet Transplantation. Pathogenesis of Autoimmune Diabetes. Section II: Molecular and Cellular Aspects of Insulin Synthesis and Secretion. Insulin Gene Structure and Regulation. Molecular Engineering of Glucose-Regulated Insulin Secretion. Glucokinase Gene Expression and Regulation. Fundamentals of Fuel Sensing and Intermediary Metabolism in Pancreatic A- and B-Cells. Glucose Toxicity and the Insulin Gene. Proinsulin-Processing Endopeptidases. GTP and Its Binding Proteins in the Regulation of Insulin Exocytosis. Beta Cell Receptors: Mechanisms of Signal Transduction. Molecular Biology of the Ion Channels in the Pancreatic b-Cell. Molecular Biology of Gap-Junction Proteins. The Gluco-Incretin Hormone Glucagon-Like Peptide-1 and Its b-Cell Receptor. Islet Amyloid Polypeptide (IAPP) and Insulin Secretion. Index.
520 ## - SUMMARY, ETC.
Summary, etc In type II diabetes, an abnormality in pancreatic secretion exists concomitantly with peripheral insulin resistance. In this volume, we have invited authors to describe their studies on all known factors affecting ~-cell function, including autoimmunity and genetics of diabetes, as well as molecular mecha nisms of insulin synthesis and secretion.
520 ## - SUMMARY, ETC.
Summary, etc In a rapidly evolving and extremely important area of medical science, it is often difficult for the student, teacher, and researcher to keep abreast of all the important advances. The purpose of Molecular Biology ofDiabetes, Parts I and II is to bring to these individuals the latest knowledge of diabetes-related research in a comprehensive, yet concise manner. To this end, we have assembled chapters, written by most of the world's experts in the field, that we believe compre hensively survey and synthesize a coherent understanding of the subject. Studies of the etiology of type I and type II diabetes are extremely exciting and essential, since we hope to one day prevent the disease using gene therapy. These aspects are covered in Molecular Biology of Diabetes: I. Autoimmunity and Genetics; Insulin Synthesis and Secretion. In type II diabetes, an abnormality in pancreatic secretion exists concomitantly with peripheral insulin resistance. This abnor mality of insulin secretion is believed to be related to a defect(s) in glucose sensing. Uncoupling of glucose sensing from insulin secre tion may be the crucial step in the pathogenesis of noninsulin-depen dent diabetes. In this volume, we have invited authors to describe their studies on all known factors affecting ~-cell function, including autoimmunity and genetics of diabetes, as well as molecular mecha nisms of insulin synthesis and secretion. In the last few years, the most rapidly advancing area of research in diabetes has been, in fact, related to insulin action.
690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN)
Department Name Life Science
700 ## - ADDED ENTRY--PERSONAL NAME
Personal name Derek LeRoith.
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Source of classification or shelving scheme Dewey Decimal Classification
Koha item type General Books
Holdings
Withdrawn status Lost status Source of classification or shelving scheme Damaged status Not for loan Collection code Home library Location Shelving location Date of Cataloging Total Checkouts Full call number Barcode Date last seen Price effective from Koha item type
    Dewey Decimal Classification     Non-fiction CUTN Central Library CUTN Central Library Medicine, Technology & Management 09/08/2021   616.462 DRA 44231 09/08/2021 09/08/2021 General Books