Molecular biology of human cancers : an advanced student's textbook

By:

Wolfgang Arthur Schulz

Material type: Text

TextLanguage: English Publication details: Dordrecht ; [Great Britain] : Springer, 2005.Edition: 1st edDescription: xvii, 508 p. : ill. ; 25 cmISBN:

9781402031854

Subject(s):

DDC classification:

616.994 SCH

Contents:

Contents : Front Matter Pages i-xvii PDF Molecules, Mechanisms, And Cells Front Matter PDF An Introduction to Human Cancers Pages 1-23 An Introduction to Human Cancers Pages 25-46 DNA Damage and DNA Repair Pages 47-70 Oncogenes Pages 71-90 Tumor Suppressor Genes Pages 91-112 Cancer Pathways Pages 113-144 Apoptosis and Replicative Senescence in Cancer Pages 145-165 Cancer Epigenetics Pages 167-192 Invasion and metastasis Pages 193-217 Human Cancers Front Matter PDF Leukemias and Lymphomas Pages 219-242 Wilms Tumor (nephroblastoma) Pages 243-253 Cancers of the skin Pages 255-270 Colon Cancer Pages 271-288 Bladder Cancer Pages 289-306 Renal Cell Carcinoma Pages 307-326 Liver Cancer Pages 327-340 Stomach Cancer Pages 341-355 Human Cancers Breast Cancer Pages 357-382 Prostate Cancer Pages 383-402 Prevention, Diagnosis, And Therapy Front Matter PDF Cancer Prevention Pages 403-426 Cancer Diagnosis Pages 427-447 Cancer Therapy Pages 449-488

Summary: Over the last three decades, knowledge on the molecular biology of human cancers has vastly expanded. A host of genes and proteins involved in cancer development and progression have been defined and many mechanisms at the molecular, cellular and even tissue level have been, at least partly, elucidated. Insights have also been gained into the molecular mechanisms underlying carcinogenesis by chemical, physical, and biological agents and into inherited susceptibility to cancer. Accordingly, Part I of the book presents many of the molecules and mechanisms generally important in human cancers. Following an overview on the cancer problem, individual chapters deal with cancer genetics and epigenetics, DNA damage and repair, oncogenes, tumor suppressors, regulatory pathways in cancer, apoptosis, cellular senescence, tumor invasion, and metastasis. A consensus is emerging that while these common mechanisms and molecules are all relevant to human cancers, in each cancer type (or even subtype) a selection of them are extremely important. For selected cancers, the route from genetic and epigenetic changes to their biological and clinical behavior can already be traced. Part II of the book presents a broad, but exemplary selection of cancers that serve as paradigms to illustrate this point. In fact, cancer research has now reached a critical stage, in which the accumulated knowledge on molecular mechanisms is gradually translated into improved prevention, diagnosis, and treatment. The state, pitfalls, and potential of these efforts are summarized in Part III. More than ever, cancer research is now an interdisciplinary effort which requires a basic knowledge of commonly used terms, facts, issues, and concepts. The aim of this book is to provide advanced students and practitioners of different disciplines with this basis, bridging the gap between standard textbooks of molecular biology, pathology, and oncology on the one hand and the specialized cancer literature on the other.

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Holdings
Item type	Current library	Collection	Call number	Status	Date due	Barcode
Reference Books	CUTN Central Library Reference	Non-fiction	616.994 SCH (Browse shelf(Opens below))	Not for loan		44194

Contents :

Front Matter
Pages i-xvii
PDF
Molecules, Mechanisms, And Cells
Front Matter
PDF
An Introduction to Human Cancers
Pages 1-23
An Introduction to Human Cancers
Pages 25-46
DNA Damage and DNA Repair
Pages 47-70
Oncogenes
Pages 71-90
Tumor Suppressor Genes
Pages 91-112
Cancer Pathways
Pages 113-144
Apoptosis and Replicative Senescence in Cancer
Pages 145-165
Cancer Epigenetics
Pages 167-192
Invasion and metastasis
Pages 193-217
Human Cancers
Front Matter
PDF
Leukemias and Lymphomas
Pages 219-242
Wilms Tumor (nephroblastoma)
Pages 243-253
Cancers of the skin
Pages 255-270
Colon Cancer
Pages 271-288
Bladder Cancer
Pages 289-306
Renal Cell Carcinoma
Pages 307-326
Liver Cancer
Pages 327-340
Stomach Cancer
Pages 341-355

Human Cancers
Breast Cancer
Pages 357-382
Prostate Cancer
Pages 383-402
Prevention, Diagnosis, And Therapy
Front Matter
PDF
Cancer Prevention
Pages 403-426
Cancer Diagnosis
Pages 427-447
Cancer Therapy
Pages 449-488

Over the last three decades, knowledge on the molecular biology of human cancers has vastly expanded. A host of genes and proteins involved in cancer development and progression have been defined and many mechanisms at the molecular, cellular and even tissue level have been, at least partly, elucidated. Insights have also been gained into the molecular mechanisms underlying carcinogenesis by chemical, physical, and biological agents and into inherited susceptibility to cancer.

Accordingly, Part I of the book presents many of the molecules and mechanisms generally important in human cancers. Following an overview on the cancer problem, individual chapters deal with cancer genetics and epigenetics, DNA damage and repair, oncogenes, tumor suppressors, regulatory pathways in cancer, apoptosis, cellular senescence, tumor invasion, and metastasis.

A consensus is emerging that while these common mechanisms and molecules are all relevant to human cancers, in each cancer type (or even subtype) a selection of them are extremely important. For selected cancers, the route from genetic and epigenetic changes to their biological and clinical behavior can already be traced. Part II of the book presents a broad, but exemplary selection of cancers that serve as paradigms to illustrate this point.

In fact, cancer research has now reached a critical stage, in which the accumulated knowledge on molecular mechanisms is gradually translated into improved prevention, diagnosis, and treatment. The state, pitfalls, and potential of these efforts are summarized in Part III.

More than ever, cancer research is now an interdisciplinary effort which requires a basic knowledge of commonly used terms, facts, issues, and concepts. The aim of this book is to provide advanced students and practitioners of different disciplines with this basis, bridging the gap between standard textbooks of molecular biology, pathology, and oncology on the one hand and the specialized cancer literature on the other.

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