"A subject collection from Cold Spring Harbor perspectives in biology"--T.p. verso.

Includes bibliographical references and index.

Deciphering Alzheimer disease / Dennis Selkoe, David Holtzman, and Eckhard Mandelkow -- The clinical problem of symptomatic Alzheimer disease and mild cognitive impairment / John C. Morris -- The neuropsychological profile of Alzheimer disease / Sandra Weintraub, Alissa H. Wicklund, and David P. Salmon -- Neuropathological alterations in Alzheimer disease / Alberto Serrano-Pozo ... [et al.] -- Brain imaging in Alzheimer disease / Keith A. Johnson ... [et al.] -- Fluid biomarkers in Alzheimer disease / Kaj Blennow, Henrik Zetterberg, and Anne M. Fagan -- Epidemiology of Alzheimer disease / Richard Mayeux and Yaakov Stern -- Biochemistry and cell biology of tau protein in neurofibrillary degeneration / Eva Mandelkow and Eckhard Mandelkow -- Frontotemporal dementia : implications for understanding Alzheimer disease / Michel Goedert, Bernardino Ghetti, and Maria Grazia Spillantini -- Biochemistry of amyloid deposition in Alzheimer disease / Colin L. Masters and Dennis J. Selkoe -- Trafficking and proteolytic processing of APP / Christian Haass ... [et al.] -- Physiological functions of APP family proteins / Ulrike C. Møller and Hui Zheng -- The genetics of Alzheimer disease : APP, presenilin, apolipoprotein E, and the search for other genes / Rudolph E. Tanzi and Peter St. George-Hyslop -- Presenilins and [gamma]-secretase : structure, function, and role in Alzheimer disease / Bart de Strooper, Takeshi Iwatsubo, and Michael S. Wolfe -- Apolipoprotein E and apolipoprotein E receptors : normal biology and roles in AD / David M. Holtzman, Joachim Herz, and Guojun Bu -- Modeling genetic forms of Alzheimer disease in animals / Karen Duff and Frank Laferla -- Neurotoxicity of amyloid-beta protein : synaptic and network dysfunction / Leonard Mucke and Dennis J. Selkoe -- Inflammation in Alzheimer disease : a brief review of the basic science and clinical literature / Tony Wyss-Coray and Joseph Rogers -- The ubiquitin-proteasome system and autophagy in Alzheimer disease / Yasuo Ihara and Ralph Nixon -- Proteolytic degradation of amyloid [beta]-protein / Takaomi Saido and Malcolm A. Leissring -- Treatment strategies targeting beta amyloid peptide / Dale Schenk -- Developing therapeutic approaches to tau, selected kinases, and related neuronal protein targets / Virginia M-Y. Lee ... [et al.] -- Symptomatic and non-amyloid/tau based pharmacologic treatment for Alzheimer disease / Paul S. Aisen, Jeffrey L. Cummings, and Lon S. Schneider -- Alzheimer disease in 2020 / David Holtzman, Dennis J. Selkoe, and Eckhard Mandelkow.