Brain stem cells / edited by J. A. Miyan ... [et al.]

Brain Stem Cells provides a detailed analysis of the mechanisms which underline both the neuronal and cortical development of the brain. Recent studies have led to the identification and characterisation of brain stem cells and it is now clear that these cells continue to develop throughout adult life. This raises the prospect of treating brain-damaged patients with neurons cultured from their own stem cells. Written by leading experts in the field, this book will be essential reading for all those with an interest in this fast-developing area.

Neural stem cells of the mammalian forebrain; similarity and differences between the haemopoietic and brain stem cell system; lineage selection and isolation of neural precursors from embryonic stem cells; early generated Cajal-Retzius cells have different functions in cortical development; signalling cascade of CNR cadherins (Reelin receptors) in the mammalian brain; the role of the Reelin pathway in cortical development; the "Drosophila" nervous system as a model for assymetric cell division; developmental abnormalities in early-onset hydrocephalus - clues to signaling; stem cells and regeneration in invertebrate deuterostomes.

Includes bibliographical references and index.