Neuroinflammation : mechanisms and management / edited by Paul L. Wood.

Contributor(s):

Wood, Paul L

Material type: Text

TextSeries: Contemporary neurosciencePublication details: Totowa, N.J. : Humana Press, c2003.Edition: 2nd edDescription: 419 p. : ill. ; 35 cmISBN:

1588290026 (alk. paper)

Subject(s):

DDC classification:

616.804 21 WOO

LOC classification:

RC363 .N48 2003

NLM classification:

WL 359

Online resources:

Contents:

Preface ............................................................................................................................ v Contributors...................................................................................................................ix I. NEUROINFLAMMATORY MECHANISMS 1 Microglia: Roles of Microglia in Chronic Neurodegenerative Diseases ........................................................................................ 3 Paul L. Wood 2 Apoptosis vs Nonapoptotic Mechanisms in Neurodegeneration ................................................................. 29 Kurt A. Jellinger 3 Role(s) of Mitogen and Stress-Activated Kinases in Neurodegeneration .................................................................. 89 Christopher C. J. Miller, Steven Ackerley, Janet Brownlees, Andrew J. Grierson, and Paul Thornhill 4 Roles of Chemokines and Their Receptors in Neuroinflammation ................................................................ 99 Andrzej R. Glabinski and Richard M. Ransohoff 5 Neurotoxic Mechanisms of Nitric Oxide ..................................... 117 Kathleen M. K. Boje 6 Chronic Intracerebral LPS as a Model of Neuroinflammation ...... 137 Gary L. Wenk and Beatrice Hauss-Wegrzyniak 7 Peroxisome Proliferator-Activated Receptor Gamma Agonists: Potential Therapeutic Agents for Neuroinflammation ............ 151 Gary E. Landreth, Sophia Sundararajan, and Michael T. Heneka 8 Neuroinflammation-Mediated Neurotoxin Production in Neurodegenerative Diseases: Potential of Nitrones as Therapeutics......................................................................... 171 Robert A. Floyd and Kenneth Hensley II. STROKE AND TBI 9 Inflammation and Potential Anti-Inflammatory Approaches in Stroke .................................................................................... 189 Jari Koistinaho and Juha Yrjänheikki 10 Neuroinflammation as an Important Pathogenic Mechanism in Spinal Cord Injury ................................................................ 215 Yuji Taoka and Kenji Okajima 11 Type IV Collagenases and Blood-Brain Barrier Breakdown in Brain Ischemia ...................................................................... 237 Yvan Gasche, Jean-Christophe Copin, and Pak H. Chan CONTENTS vii III. ALZHEIMER’S DISEASE 12 Neuroinflammatory Environments Promote Amyloid-β Deposition and Posttranslational Modification ....................... 249 Craig S. Atwood, Mark A. Smith, Ralph N. Martins, Rudolph E. Tanzi, Alex E. Roher, Ashley I. Bush, and George Perry 13 Microglial Responses in Alzheimer’s Disease: Recent Studies in Transgenic Mice and Alzheimer’s Disease Brains.............. 267 Douglas G. Walker and Lih-Fen Lue 14 The Amyloid Hypothesis of Cognitive Dysfunction ................... 283 Dave Morgan and Marcia N. Gordon 15 The Cerebellum in AD: A Case for Arrested Neuroinflammation? ................................................................. 295 Paul L. Wood 16 The Neuroinflammatory Components of the Trimethyltin (TMT) Model of Hippocampal Neurodegeneration ................ 301 G. Jean Harry and Christian Lefebvre d’Hellencourt 17 Inflammation and Cyclo-Oxygenase in Alzheimer’s Disease: Experimental Approaches and Therapeutic Implications ....... 331 Patrick Pompl, Tara Brennan, Lap Ho, and Giulio Maria Pasinetti IV. MULTIPLE SCLEROSIS 18 Experimental Autoimmune Encephalomyelitis ........................... 345 Hans-Peter Hartung and Bernd C. Kieseier 19 Neuroimmunologic Mechanisms in the Etiology of Multiple Sclerosis .................................................................................... 359 Claudia F. Lucchinetti, W. Brück, and Hans Lassmann 20 In Vivo Imaging of Neuroinflammation in Neurodegenerative Diseases .................................................................................... 379 Annachiara Cagnin, Alexander Gerhard, and Richard B. Banati V. PARKINSON’S AND HUNTINGTON’S DISEASES 21 Inflammatory Mechanisms in Parkinson’s Disease ..................... 391 Joseph Rogers and Carl J. Kovelowski 22 Neuroinflammatory Components of the 3-Nitropropionic Acid Model of Striatal Neurodegeneration....................................... 405 Hideki Hida, Hiroko Baba, and Hitoo Nishino Index ........................................................................................................................... 417

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Holdings
Item type	Current library	Collection	Call number	Status	Date due	Barcode
General Books	CUTN Central Library Medicine, Technology & Management	Non-fiction	616.804 WOO (Browse shelf(Opens below))	Available		42969

Includes bibliographical references and index.

Preface ............................................................................................................................ v
Contributors...................................................................................................................ix
I. NEUROINFLAMMATORY MECHANISMS
1 Microglia: Roles of Microglia in Chronic Neurodegenerative
Diseases ........................................................................................ 3
Paul L. Wood
2 Apoptosis vs Nonapoptotic Mechanisms
in Neurodegeneration ................................................................. 29
Kurt A. Jellinger
3 Role(s) of Mitogen and Stress-Activated Kinases
in Neurodegeneration .................................................................. 89
Christopher C. J. Miller, Steven Ackerley, Janet Brownlees,
Andrew J. Grierson, and Paul Thornhill
4 Roles of Chemokines and Their Receptors
in Neuroinflammation ................................................................ 99
Andrzej R. Glabinski and Richard M. Ransohoff
5 Neurotoxic Mechanisms of Nitric Oxide ..................................... 117
Kathleen M. K. Boje
6 Chronic Intracerebral LPS as a Model of Neuroinflammation ...... 137
Gary L. Wenk and Beatrice Hauss-Wegrzyniak
7 Peroxisome Proliferator-Activated Receptor Gamma Agonists:
Potential Therapeutic Agents for Neuroinflammation ............ 151
Gary E. Landreth, Sophia Sundararajan,
and Michael T. Heneka
8 Neuroinflammation-Mediated Neurotoxin Production
in Neurodegenerative Diseases: Potential of Nitrones
as Therapeutics......................................................................... 171
Robert A. Floyd and Kenneth Hensley
II. STROKE AND TBI
9 Inflammation and Potential Anti-Inflammatory Approaches
in Stroke .................................................................................... 189
Jari Koistinaho and Juha Yrjänheikki
10 Neuroinflammation as an Important Pathogenic Mechanism
in Spinal Cord Injury ................................................................ 215
Yuji Taoka and Kenji Okajima
11 Type IV Collagenases and Blood-Brain Barrier Breakdown
in Brain Ischemia ...................................................................... 237
Yvan Gasche, Jean-Christophe Copin, and Pak H. Chan
CONTENTS
vii
III. ALZHEIMER’S DISEASE
12 Neuroinflammatory Environments Promote Amyloid-β
Deposition and Posttranslational Modification ....................... 249
Craig S. Atwood, Mark A. Smith, Ralph N. Martins,
Rudolph E. Tanzi, Alex E. Roher, Ashley I. Bush,
and George Perry
13 Microglial Responses in Alzheimer’s Disease: Recent Studies
in Transgenic Mice and Alzheimer’s Disease Brains.............. 267
Douglas G. Walker and Lih-Fen Lue
14 The Amyloid Hypothesis of Cognitive Dysfunction ................... 283
Dave Morgan and Marcia N. Gordon
15 The Cerebellum in AD: A Case for Arrested
Neuroinflammation? ................................................................. 295
Paul L. Wood
16 The Neuroinflammatory Components of the Trimethyltin
(TMT) Model of Hippocampal Neurodegeneration ................ 301
G. Jean Harry and Christian Lefebvre d’Hellencourt
17 Inflammation and Cyclo-Oxygenase in Alzheimer’s Disease:
Experimental Approaches and Therapeutic Implications ....... 331
Patrick Pompl, Tara Brennan, Lap Ho,
and Giulio Maria Pasinetti
IV. MULTIPLE SCLEROSIS
18 Experimental Autoimmune Encephalomyelitis ........................... 345
Hans-Peter Hartung and Bernd C. Kieseier
19 Neuroimmunologic Mechanisms in the Etiology of Multiple
Sclerosis .................................................................................... 359
Claudia F. Lucchinetti, W. Brück, and Hans Lassmann
20 In Vivo Imaging of Neuroinflammation in Neurodegenerative
Diseases .................................................................................... 379
Annachiara Cagnin, Alexander Gerhard,
and Richard B. Banati
V. PARKINSON’S AND HUNTINGTON’S DISEASES
21 Inflammatory Mechanisms in Parkinson’s Disease ..................... 391
Joseph Rogers and Carl J. Kovelowski
22 Neuroinflammatory Components of the 3-Nitropropionic Acid
Model of Striatal Neurodegeneration....................................... 405
Hideki Hida, Hiroko Baba, and Hitoo Nishino
Index ........................................................................................................................... 417

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