Frontmatter -- Contents -- Preface -- 1 Microbial Design -- Part 1 Theoretical Background -- 2 Forces of Design -- 3 Comparison and Causality -- 4 Brief Examples -- 5 Theory: Forces -- 6 Theory: Traits -- 7 Theory: Control -- 8 Studying Biological Design -- Part 2 The Design of Metabolism -- 9 Microbial Metabolism -- 10 Growth Rate -- 11 Thermodynamics: Biochemical Flux -- 12 Flux Modulation: Driving Force -- 13 Flux Modulation: Resistance -- 14 Variant Pathways -- 15 Tradeoffs -- 16 Predictions: Overflow Metabolism -- 17 Predictions: Diauxie, Electrons, Storage -- 18 Design Revisited -- References -- Index

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A powerful framework for understanding how natural selection shapes adaptation and biological designDesign and diversity are the two great challenges in the study of life. Microbial Life History draws on the latest advances in microbiology to describe the fundamental forces of biological design and apply these evolutionary processes to a broad diversity of traits in microbial metabolism and biochemistry.Emphasizing how to formulate and test hypotheses of adaptation, Steven Frank provides a new foundation for exploring the evolutionary forces of design. He discusses the economic principles of marginal valuations, trade-offs, and payoffs in risky and random environments; the social aspects of conflict and cooperation; the demographic aspects of age and spatial heterogeneity; and the engineering control theory principles by which systems adjust to environments. Frank then applies these evolutionary principles to the biochemistry of microbial metabolism, providing the first comprehensive link between the forces that shape biological design and cellular energetics.Tracing how natural selection sculpts metabolism, Microbial Life History provides new perspectives on the life histories of organisms, from growth rate and survival to dispersal and defense against attack. Along the way, this incisive book addresses the conceptual and philosophical challenges confronting evolutionary biologists and other practitioners who study biological design and seek to apply its lessons.

Mode of access: Internet via World Wide Web.

Steven A. Frank is Donald Bren Professor of Biological Sciences at the University of California, Irvine. His books include Dynamics of Cancer, Immunology and Evolution of Infectious Disease, and Foundations of Social Evolution (all Princeton).

In English.

Description based on online resource; title from PDF title page (publisher's Web site, viewed March 03 2026)